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Mastectomy

Learn about the steps that high-risk women can take to manage their risk and protect their health.

Advanced Reading

Time to reconsider subcutaneous mastectomy for breast-cancer prevention?
Kelly Metcalfe, Semple JL, Narod SA. The Lancet Oncology. Volume 6, Number 6: p. 431-434, June 2005.

Cytokeratin-positive cells in sentinel lymph nodes in breast cancer are not random events
King TA, Ganaraj A, Fey JV, Tan LK, Hudis C, Norton L, Cody HS 3rd, Borgen PI. Cancer. Volume 101, Issue 5: p. 926-33, September 2004.

Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group
Timothy R. Rebbeck, Tara Friebel, Henry T. Lynch, Susan L. Neuhausen, Laura van 't Veer, Judy E. Garber, Gareth R. Evans, Steven A. Narod, Claudine Isaacs, Ellen Matloff, Mary B. Daly, Olufunmilayo I. Olopade, and Barbara L. Weber. Journal of Clinical Oncology. Volume 22, Number 6: p. 1055-1062, February 2004.

Reoperations after prophylactic mastectomy with or without implant reconstruction
Zion SM, Slezak JM, Sellers TA, Woods JE, Arnold PG, Petty PM, Donohue JH, Frost MH, Schaid DJ, Hartmann LC. Cancer. Volume 98, Number 10:p2152-60, November 2003.

Genetic testing for a BRCA1 mutation: Prophylactic surgery and screening behavior in women 2 years post testing
Jeffrey R. Botkin, Ken R. Smith, Robert T. Croyle, Bonnie J. Baty, Jean E. Wylie, Debra Dutson, Anna Chan, Heidi A. Hamann, Caryn Lerman, Jamie McDonald, Vickie Venne, John H. Ward, Elaine Lyon. American Journal of Medical Genetics. Volume 118A, Issue 3: p. 201-209, Feb. 2003.

Effect of Prevention Strategies on Survival and Quality-Adjusted Survival of Women With BRCA1/2 Mutations: An Updated Decision Analysis
Victor R. Grann, Judith S. Jacobson, Dustin Thomason, Dawn Hershman, Daniel F. Heitjan, Alfred I. Neugut. Journal of Clinical Oncology. Volume 20, Issue 10: p. 2520-2529, May 2002.

Outcome of Preventive Surgery and Screening for Breast and Ovarian Cancer in BRCA Mutation Carriers
By Lauren Scheuer, Noah Kauff, Mark Robson, Bridget Kelly, Richard Barakat, Jaya Satagopan, Nathan Ellis, Martee Hensley, Jeff Boyd, Patrick Borgen, Larry Norton, Kenneth Offit. Journal of Clinical Oncology. Volume 20, Issue 5: p. 1260-1268, March 2002.

Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers
Hartmann LC, Sellers TA, Schaid DJ, Frank TS, Soderberg CL, Sitta DL, Frost MH, Grant CS, Donohue JH, Woods JE, McDonnell SK, Vockley CW, Deffenbaugh A, Couch FJ, Jenkins RB. Journal of the National Cancer Institute. Volume 93, Number 21:p1633-7, November 2001.

Life Expectancy Gains From Cancer Prevention Strategies for Women With Breast Cancer and BRCA1 or BRCA2 Mutations
Deborah Schrag, MD, MPH; Karen M. Kuntz, ScD; Judy E. Garber, MD, MPH; Jane C. Weeks, MD, MSc. Journal of the American Medical Association. Volume 283: p. 617-624, February 2000.

Breast Cancer after Prophylactic Bilateral Mastectomy in Women with a BRCA1 or BRCA2 Mutation
Hanne Meijers-Heijboer, M.D., Bert van Geel, M.D., Ph.D., Wim L.J. van Putten, M.Sc., Sonja C. Henzen-Logmans, M.D., Ph.D., Caroline Seynaeve, M.D., Ph.D., Marian B.E.,Menke-Pluymers, M.D., Ph.D., Carina C.M. Bartels, M.D., Leon C. Verhoog, M.D., Ans M.W. van den Ouweland, Ph.D., Martinus F. Niermeijer, M.D., Ph.D., Cecile T.M. Brekelmans, M.D., Ph.D., and Jan G.M. Klijn, M.D., Ph.D. New England Journal of Medicine. Volume 345: p. 159-164, July 2001.

Efficacy of Bilateral Prophylactic Mastectomy in Women with a Family History of Breast Cancer
Lynn C. Hartmann, M.D., Daniel J. Schaid, Ph.D., John E. Woods, M.D., Thomas P. Crotty, M.D., Jeffrey L. Myers, M.D., P.G. Arnold, M.D., Paul M. Petty, M.D., Thomas A. Sellers, Ph.D., Joanne L. Johnson, R.N., Shannon K. McDonnell, M.S., Marlene H. Frost, Ph.D., R.N., Robert B. Jenkins, M.D., Ph.D., Clive S. Grant, M.D., and Virginia V. Michels, M.D. New England Journal of Medicine. Volume 340: p. 77-84, January 1999.