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Hereditary Cancer Info > Risk Management > Risk Management Guidelines

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Risk Management Guidelines

Learn about the steps that people at high risk for cancer can take to manage their risk and protect their health.

NCCN Guidelines for Women with Mutations in PALB2, ATM, CHEK2, NBN, NF1 BRIP1, RAD51C, and RAD51D

Breast Cancer Screening: 

  • Annual screening mammogram (consider 3D mammography) and annual MRI with contrast beginning at age 30, or earlier based on family breast cancer history for women with mutations in following genes:
    • PALB2‚Äč
    • NF1

 

  • Annual screening mammogram (consider 3D mammography) and annual MRI with contrast beginning at age 40, or earlier based on family breast cancer history for women with mutations in following genes:
    • ATM
    • CHEK2
    • NBN

Breast Cancer Risk Management

  • Discussing the option of risk-reducing mastectomy based of family history of breast cancer for women with mutations in:
    • ATM
    • CHEK2
    • NBN
    • NF1
    • PALB2

Ovarian Cancer Risk Management

  • Women with mutations in following genes should consider risk-reducing removal of ovaries and fallopian tubes at age 45-50:
    • BRIP1
    • RAD51C
    • RAD51D

Updated 11/8/16

 

 

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