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Hereditary Cancer Info > Risk Management > Risk Management Guidelines

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Risk Management Guidelines

Learn about the steps that people at high risk for cancer can take to manage their risk and protect their health.

NCCN Guidelines for risk management for men and women with Lynch Syndrome

Guidelines for women

  • Consider risk-reducing removal of ovaries and uterus upon completion of childbearing
  • Women should be educated on possible symptoms of ovarian or uterine cancer. They should report any unusual vaginal bleeding, pelvic or abdominal pain, bloating, increased abdominal girth, difficulty eating, or increased urinary frequency or urgency to health care providers immediately
  • Consider screening via endometrial biopsy every 1-2 years
  • Manage breast cancer risk based on family history

Guidelines for men and women

  • Colonoscopy at age 20-25 (or 2-5 years prior earliest colon cancer in the family) every 1-2 years
  • There is data suggesting that aspirin can decrease the risk for colon cancer in Lynch Syndrome but the best dosing has not been established
  • Consider gastric cancer screening by EGD every 3-5 years beginning at age 40 if there is a family history of gastric cancer and/or Asian ancestry. If gastric screening is performed, considered testing for and treating H. pylori.
  • Consider annual urinalysis beginning age 30-35, especially for people from families with a family history of urothelial cancer and individuals with a MSH2 mutation. 
  • Consider annual physical and neurological exam starting at age 25-30.

Reproductive options

  • For patients of reproductive age, advise about options for prenatal diagnosis and assisted reproduction including pre-implantation genetic diagnosis. 

Risk to relatives

  • Advise about possible inherited cancer risk to relatives, options for risk assessment, and management. 
  • Recommend genetic counseling and consideration of genetic testing for at-risk relatives. 

Updated 11/05/2018

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