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Jewish People

Learn more about how HBOC affects members of specific populations.

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Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and pancreatic cancer
Stadler ZK, Salo-Mullen E, Patil SM, Pietanza MC, Vijai J, Saloustros E, Hansen NA, Kauff ND, Kurtz RC, Kelsen DP, Offit K, Robson ME. Cancer, Volume 117 (23). May, 2007.

Double heterozygosity in the BRCA1 and BRCA2 genes in the Jewish population
Lavie O, Narod S, Lejbkowicz F, Dishon S, Goldberg Y, Gemer O, Rennert G. Annals of Oncology. Volume 22(4), p. 964-966. April, 2011.

Relative contributions of BRCA1 and BRCA2 mutations to "triple-negative" breast cancer in Ashkenazi Women
Comen E, Davids M, Kirchhoff T, Hudis C, Offit K, Robson M. Breast Cancer Res Treat. Volume 129(1):185-90, Aug. 2011. Epub March, 2011.

Two BRCA1/2 founder mutations in Jews of Sephardic origin
Sagi M, Eilat A, Ben Avi L, Goldberg Y, Bercovich D, Hamburger T, Peretz T, Lerer I. Familial Cancer. Volume 10(1), p. 59-63. March, 2011.

Clinical and molecular features associated with biallelic mutations in FANCD1/BRCA2
Alter BP, Rosenberg PS, Brody LC. Journal of Medical Genetics. Volume 44 (1) p. 1-9, January, 2007.

Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: Analysis of 10,000 individuals
Thomas S. Frank, Amie M. Deffenbaugh, Julia E. Reid, Mark Hulick, Brian E. Ward, Beth Lingenfelter, Kathi L. Gumpper, Thomas Scholl, Sean V. Tavtigian, Dmitry R. Pruss, Gregory C. Critchfield. Journal of Clinical Oncology. Volume 20, Issue 6: p. 1480-1490, March 2002.

The lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations
Jaya M. Satagopan, Kenneth Offit, William Foulkes, Mark E. Robson, Sholom Wacholder, Christine M. Eng, Stephen E. Karp and Colin B. Begg. Cancer Epidemiology Biomarkers & Prevention. Volume 10: p. 467-473, May 2001. (Full text)

The Risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews
Jeffery P. Struewing, M.D., Patricia Hartge, Sc.D., Sholom Wacholder, Ph.D., Sonya M. Baker, B.S., Martha Berlin, B.A., Mary McAdams, M.S., Michelle M. Timmerman, B.S., Lawrence C. Brody, Ph.D., and Margaret A. Tucker, M.D. New England Journal of Medicine. Volume 336, Number 20: p. 1401-1408, May 1997.

Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States)
Modugno F, Moslehi R, Ness RB, Nelson DB, Belle S, Kant JA, Wheeler JE, Wonderlick A, Fishman D, Karlan B, Risch H, Cramer DW, Dube MP, Narod SA. Cancer Causes Control. Volume 5: p. 439-46, June 2003. (Pubmed abstract)

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