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Inherited mutations in the SKT11 gene are associated with Peutz-Jeghers syndrome, a rare disorder that leads to increased risk of noncancerous growths and increased risk of certain cancers.
People with STK11 mutations are at a greatly increased risk of:
People with Peutz-Jeghers syndrome also tend to develop noncancerous polyps in the stomach and intestine. Children with this syndrome often have dark spots in or near the mouth, eyes, nostrils and/or fingers.
National guidelines for managing cancer risk in people with inherited SKT11 mutations recommend:
A genetics expert can look at your personal and family medical history and see if it is consistent with Peutz-Jeghers syndrome and order testing if appropriate.