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Although rare, pancreatic cancer can be caused by an inherited mutation in BRCA or other genes. Some experts advocate genetic testing for all pancreatic adenocarcinoma patients, as this information may be critical for other family members in terms of screening and prevention. Recent studies analyzing the number of pancreatic cancer patients who have an inherited mutation in BRCA found that:
Other gene mutations which may increase the risk for pancreatic cancer include:
Benefits of genetic testing for people with pancreatic cancer include:
Test results may affect treatment decisions. For example, research has shown that people with hereditary pancreatic cancer may respond favorably to a type of chemotherapy known as platinum.
Test results may affect eligibility for certain clinical trials for targeted therapy.