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BRCA & HBOC
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BRCA & Infertility

Learn about the effects of HBOC on fertility and family planning, how pregnancy impacts hereditary cancer risk, and options for assisted reproduction.

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Comparison of age at natural menopause in BRCA1/2 mutation carriers with a non-clinic-based sample of women in northern California.
Cancer. 2013 May 1;119(9):1652-9. Lin WT, Beattie M, Chen LM, Oktay K, Crawford SL, Gold EB, Cedars M, Rosen M.

Compared to women without known mutations, mutation carriers experienced menopause three years sooner than women who had not been tested for the mutation.

Association of BRCA1 Mutations With Occult Primary Ovarian Insufficiency: A Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
Journal of Clinical Oncology, Vol 28, No 2 (January 10), 2010: pages. 240-244. Kutluk Oktay, Ja Yeon Kim, David Barad, Samir N. Babayev.

Small study which suggests that women with BRCA1 mutations may not respond as well to infertility treatment as women with no BRCA1 mutation.

Fertility in women with BRCA mutations: a case-control study.
Fertil Steril. 2010 Apr;93(6):1805-8. Pal T, Keefe D, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group.

Study suggests that women who have a BRCA mutation are no more likely to experience infertility than women without a mutation.

FORCE:Facing Our Risk of Cancer Empowered