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Chemotherapy

Learn how genetic test results may affect medical decisions about cancer treatment.”

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BRCA mutation testing in determining breast cancer therapy
Smith, KL and Isaacs, C. Cancer J. 17(6):2011 Nov-Dec; Pages: 492-499.

This article reviews surgical and treatment options for management of affected BRCA mutation carriers with breast cancer.

A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment
Mark E Robson et. al. Breast Cancer Research. Volume 6:1 2004. Pages R8-R17.

Conclusion: BRCA1 mutations, but not BRCA2 mutations, are associated with reduced survival in Ashkenazi women undergoing breast-conserving treatment for invasive breast cancer, but the poor prognosis associated with germline BRCA1 mutations is mitigated by adjuvant chemotherapy.