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BRCA & HBOC
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Immunotherapy

There are many options for treating hereditary cancers. Choice of treatment can be personalized based on cancer type, stage and genetics.

Advanced Reading

DNA Damage and Repair Biomarkers of Immunotherapy Response
Mouw K, Goldberg M, Konstantinopoulos P and D'Andrea A. Cancer Discov July 1 2017 (7) (7) 675-693; DOI: 10.1158/2159-8290.CD-17-0226

Scientific overview of the features of tumors that respond to immunotherapy with emphasis on DNA damage-repair deficits such as in people with inherited mutations.

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer
Nolan E, Savas P, Policheni A, et. al. Science Translational Medicine 07 Jun 2017:
Vol. 9, Issue 393, eaal4922.

Early research looking at treating BRCA1-mutant breast cancers with cisplatin to increase their mutational load and then combining drugs targeting two different immune checkpoint inhibitors achieved promising results in mice.

Comprehensive analysis of the clinical immuno-oncology landscape
J Tang, A Shalabi, V M Hubbard-Lucey; Comprehensive analysis of the clinical immuno-oncology landscape, Annals of Oncology, Dec. 2017.

Published in 2017, this article provides an overview of research and clinical care using immunotherapy agents in oncology.

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