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FORCE is a wealth of information and support for families with hereditary cancer. My hereditary cancer journey - and that of my previvor daughter - has been so much easier because of FORCE.
Advances in the field of genetics have led to the discovery of BRCA1, BRCA2 and several other genes that increase the risk for hereditary breast, ovarian, and related cancers (HBOC). Several genetics labs offer panel tests which include different combinations of genes. Not all the genes included in these tests have been well studied or conclusively linked to increased cancer risk. We recommend consulting with a health expert with advanced training in genetics for before undergoing genetic testing. Visit our page on genetic counseling to find a genetics expert. Below is a table with the most common mutations linked to hereditary breast, ovarian, and related cancers.
|Gene Mutation||Associated Cancer Risks|
|BRCA1 and BRCA2 (Hereditary Breast and Ovarian Cancer syndrome)||
Breast (female and male), ovarian, prostate, pancreatic, and melanoma
|PTEN (Cowden syndrome)||Breast (female), thyroid, uterine, colon, kidney, melanoma|
|TP53 (Li Freumeni syndrome)||Breast (female), sarcomas (connective tissue cancers), bone, adrenal gland, brain, leukemia, pancreatic, colon, liver, and various childhood cancers|
|STK11 (Peutz-Jeghers syndrome)||Breast (female), uterine, ovarian, colon, gastric, small bowel, pancreatic, lung, and cervical|
|MLH1, MSH2, MSH6, PMS2, EPCAM (Lynch syndrome)||Colon, uterine, ovarian, gastric, urinary tract, small bowel, and central nervous system|
|CDH1||Gastric and breast (female)|
|PALB2||Breast (female and male) and pancreatic|
|CHEK2||Breast (female and male), prostate, and colon|
|ATM||Breast (female) and pancreatic|
|NBN||Breast (female) and prostate|