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Research & Clinical Trials

FORCE has a strong commitment to promoting research to benefit our community. We advocate for more research funding, educate people about available studies, and report findings back to our community.

Research & Clinical Trials > Research Findings > BRCA1 and Brain Development

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BRCA1 and Brain Development

By Lisa Rezende, PhD

This article is in response to the press release found on this link. The press release quotes the study author who later clarified the quote used in the release.

A new research study found the BRCA1 gene to be important in the brain development of mice. Reports of the research raised concerns for some members of the BRCA1 community. Although this study is important for understanding more about the basic biology of BRCA1, it is not a clinical study and cannot be used to draw conclusions about BRCA1 mutations in humans. Dr. Inder Verma, one of the study’s authors, notes that the mice in this experiment did not have a functional copy of the BRCA1 gene. Women with BRCA1 mutations all have one functional copy of this gene. Dr. Verma told FORCE that there is no link between the results of this study and the brain development of BRCA1 mutation carriers.

Clinical research studies are designed to find out how BRCA1 mutations affect humans. At this time, there are no published research studies showing any link between BRCA1 mutations and seizures or other brain abnormalities in people.

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