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Genetics in BRCA-Negative Families with Ovarian Cancer

Other Inherited Factors in BRCA-Negative Families with Ovarian Cancer

Dr. Mary-Claire King and other researchers at the University of Washington are looking for genes beyond BRCA that may be associated with ovarian cancer risk. Families that have ovarian cancer and no identified mutation may participate in this important research. To be eligible, individuals must:

  • be BRCA1/BRCA2 mutation negative;
  • have a cancer diagnosis;
  • have either:
    -- four or more cases of breast/ ovarian cancer in the family
    -- a personal history of ovarian cancer with at least one additional invasive (not borderline) ovarian cancer in the family
    -- a personal history of breast cancer or ovarian cancer at age 40 or younger
    -- a triple-negative breast cancer (negative for estrogen and progesterone receptors and Her2/neu)

Contact Jessica Mandell, CGC (jmandell@mail.slc.edu or 540-389-5328) for more information.

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