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Other BRCA Research at the University of Pennsylvania

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Related Article

Risk-reducing Surgery

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by Sue Friedman

  • The PROSE study group is researching long-term outcomes in BRCA1/2 carriers who undergo early oophorectomy. Although effective at reducing breast and ovarian cancer risk, further information about long-term effects is needed, particularly regarding bone health and cardiovascular outcomes.
  • The University also participates in IMPACT, an international study evaluating prostate screening in men from families with BRCA1/2 mutations. Find more information and a list of participating sites at www.impact-study.co.uk/.
  • The Risk Modifier Study seeks to identify and characterize genes that affect cancer risk and clinical outcomes in people with BRCA1/2 mutations.

For more information on PROSE and other research at the University of Pennsylvania, contact their genetic counselor at 215-349-8141 or 215- 349-8143.


Domchek, SM et al., “Association of Risk- Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers with Cancer Risk and Mortality.” Journal of the American Medical Association (2010); 304:967-975.

Esserman, Laura and Kaklamani, V. “Lessons Learned from Genetic Testing.” Journal of the American Medical Association (2010); 304:1011–1012.


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