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Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Patients With Locally Advanced or Metastatic Pancreatic Cancer

Study identifier: NCT01585805
Full study details on clinicaltrials.gov

Name of PARP Inhibitor used in study:

Veliparib (Abbvie)


Male or female patients with locally advanced or metastatic pancreas adenocarcinoma with BRCA1 or 2 or PALB2 mutation.

Type of study:

Phase II study


Patients will receive one of the following treatments:

  • 21-day cycles with veliparib orally on days 1-12, gemcitabine hydrochloride intravenously and cisplatin intravenously on days 3 and 10
  • 21-day cycles with gemcitabine hydrochloride intravenously and cisplatin intravenously on days 3 and 10
  • 28-day cycles with veliparib orally on days 1-28

Study sites:

Northwestern University
Principal Investigator: Mary F. Mulcahy
Contact: Mary F. Mulcahy 312-695-4440 m-mulcahy@northwestern.edu

University of Chicago Comprehensive Cancer Center
Principal Investigator: Hedy L. Kindler
Contact: Hedy L. Kindler 773-834-7424 hkindler@medicine.bsd.uchicago.edu

Ingalls Memorial Hospital Recruiting
Principal Investigator: Mark F. Kozloff
Contact: Mark F. Kozloff 708-339-4800 mkozloff@bsd.uchicago.edu

University of Maryland Greenebaum Cancer Center
Principal Investigator: Yixing Jiang
Contact: Yixing Jiang 410-328-7225 yjiang@umm.edu

Dana-Farber Cancer Institute Recruiting
Contact: Robert J. Mayer 617-632-3473 robert_mayer@dfci.harvard.edu

University of Michigan University Hospital
Principal Investigator: Mark M. Zalupski
Contact: Mark M. Zalupski 734-615-3969 zalupski@umich.edu

Saint John's Mercy Medical Center
Principal Investigator: Bethany G. Sleckman
Contact: Bethany G. Sleckman 314-251-7057 slecbg@stlo.mercy.net

New York
New York
Memorial Sloan-Kettering Cancer Center
Principal Investigator: Eileen M. O'Reilly
Contact: Eileen M. O'Reilly 212-639-6672 oreillye@mskcc.org

Ontario Cancer Institute at Princess Margaret Hospital
Principal Investigator: Malcolm J. Moore
Contact: Malcolm J. Moore 416-946-4501 clinical.trials@uhn.on.ca

Shaare Zedek Medical Center
Contact: Amiel Segal 972-2-666-6331 segal@szmc.org.il

Tel Hashomer
Chaim Sheba Medical Center
Contact: Talia Golan 972-3-530-3030 tailia.golan@sheba.health.gov.il

Page updated 04/06/14

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