About UsNewsShop
Fighting hereditary breast and ovarian cancer
Information & Research
| More


The Study Evaluating Efficacy And Tolerability Of Veliparib in Combination With Temozolomide or In Combination With Carboplatin and Paclitaxel Versus Placebo in Subjects With BRCA1 and BRCA2 Mutation and Metastatic Breast Cancer

Note: This study is also known as the BROCADE Study BROCADE logo

Study identifier: NCT01506609
Full study details on clinicaltrials.gov

Name of PARP Inhibitor used in study:

Veliparib (Abbvie)


  • Patients with BRCA1 or BRCA2 mutation
  • Must have confirmed metastatic breast cancer
  • Her2neu negative
    • or Her2neu positive and have received previous anti-Her2neu therapy or are ineligible for anti-Her2neu therapy
  • Subjects must have measurable disease

Exlusion Criteria

  • Patients must be at least 21 days out from prior chemotherapy, radiation therapy, or investigational agent
  • May not have received more than 1 prior line of cytotoxic chemotherapy
  • May not have received prior therapy with with temozolomide, a platinum agent, or a PARP inhibitor
  • May not have received prior taxane therapy for metastatic disease
  • May not have a history of brain or leptomeningeal metastasis
  • See clinicaltrials.gov website or contact study team for other exclusion criteria

Type of study:

Phase II study


Patients are randomized to one of 3 arms:

  • Veliparib on Day 1 thru 7 and temozolomide on Day 1 thru 5 of a 28-day cycle
  • Veliparib on Day 1 thru 7 and carboplatin/paclitaxel on Day 3 of a 21-day cycle
  • Placebo on Day 1 thru 7 and carboplatin/paclitaxel on Day 3 of a 21-day cycle.

Study sites:

Contact study coordinators below where listed or for more information about all open sites:

Terri L Leahy, BA (847) 935-3179 terri.leahy@abbvie.com
Contact: Nancy Falotico (847) 937-0370 nancy.falotico@abbvie.com


  • Birmingham - Recruiting
    UAB Comprehensive Cancer Center
    Principal Investigator: Dr. Andres Forero
    Contact: Felicia Witherspoon, RN, BSN: 205-934-4317
    Valerie Caterinicchia, RN., Primary Nurse Phone: 205-934-5367 ext: 45367
    Email: Valerie.Caterinicchia@ccc.uab.edu
    Alma Del Grosso, RN., Clinical Trials Manager Email: almadelg@uab.edu


  • Little Rock
    University of Arkansas Medical Sciences
    Principal Investigator: Dr. Laura Hutchins
    Contact: Chester Wicker: 501-686-8274


  • La Jolla
    Moores UCSD Cancer Center
    Principal Investigator: Dr. Teresa Helsten
    Study coordinator: Alice Coutinho
    Phone: 858-822-6039
    Email: acoutinho@ucsd.edu
  • Los Angeles
    Cedars Sinai Medical Center
    Samuel Oschin Comprehensive Cancer Institute
    Principal Investigator: William Audeh, MD
    Research Nurse: Suzanne Swain Cabriales, RN
    Desk: 310-248-6733
    Mobile: 310-746-6006
  • Los Angeles
    The Angeles Clinic and Research Institute
    Principal Investigator: Cathie Chung, PhD, MD
    Santa Monica
    Contact: Dr. Chung: 310-582-7900
    Email: CChung@TheAngelesClinic.org
  • San Francisco
    Stanford Cancer Center
    Principal Investigator: Melinda Telli, MD
    Contact: Pei-Jen Chang: 650-725-0866


  • Aurora
    University of Colorado Hospital, Anschutz Medical Campus
    Cancer Center
    Principal Investigator: Dr. Virginia Borges
    Contact: Contact: Tessa McSpadden: 720-848-0609


  • Boca Raton
    Lynn Cancer Institute
    Principal Investigator: Dr. Jane Skelton
    Contact: Sylvie Godbout: 561-955-4800
  • Fort Lauderdale
    Holy Cross Hospital - Michael & Dianne Bienes Comprehensive Cancer Center
    Principal Investigator: Dr. Leonard Seigel
    Contact: Jorge Adames, RN: 954-267-7750
  • Tampa
    Moffitt Cancer Center
    Principal Investigator: Heather Han, MD
    Contact: Clinical research coordinators: Mira Lacevic and Dawn Carney
    Phone: 813-745-8304, 813-745-1807
  • West Palm Beach
    Palm Beach Cancer Institute
    Principal Investigator: Dr. Marilyn Raymond
    Contact: Karen Minder: 561-366-4119


  • Chicago
    Rush University Medical Center
    Principal Investigator: Lydia Usha, MD Ph: 312-563-2312
  • Chicago
    University of Chicago Medical Center
    Principal Investigator: Dr. Rita Nanda
    Contact: Jean Gibson, RN: 773-834-2167
  • Zion
    Midwestern Regional Medical Center
    Principal Investigator: Dr. Dennis Citrin
    Contact: Rebecca McQuillen: 847-731-4143


  • Annapolis
    Anne Arundel Medical Center
    Principal Investigator: Dr. Jeanine Werner
    Contact: Venita Alston Crawford, BSN RN: 443-481-4393
  • Baltimore
    Mercy Medical Center
    Principal Investigator: David A. Riseberg, MD: 410-783-5858
    Research Nurse: Lisa McConnell, RN, Ph: 410-332-1200
  • Baltimore
    Greater Baltimore Medical Center (GBMC)
    Sandra and Malcolm Berman Cancer Institute
    Principal Investigator: Dr. Madhu Chaudhry
    Contact: Garnitha Ferguson, RN: 443-849-8089
  • Baltimore
    Johns Hopkins Kimmel Cancer Center
    Principal Investigator: Dr. Vered Stearns
    Contact: Clinical Trials Specialist: 410-955-8804


  • Boston
    Massachusetts General Hospital
    Principal Investigator: Steven Isakoff, MD, PhD
    Research Nurse: Karleen Habin, RN, Ph: 617-726-1922
  • Boston
    Dana-Farber Cancer Institute
    Clinical Research Coordinator: Ryan Hodgeman Ph: 617-582-8688

  • Boston
    Beth Israel Deaconess Medical Center:
    Nadine Tung, MD
    Phone: 617-667-1962 (or have her paged at 32018)


  • Lansing
    Sparrow Cancer Center
    Principal Investigator: Dr. Gordan Srkalovic
    Contact: Vicki Gilreath, RN: 517-364-2890


  • St. Louis
    Principal Investigator: Dr. Foluso Ademuyiwa
    Contact Name: Shana Thomas
    Contact Number 314-594-7754

New Jersey

  • New Brunswick
    The Cancer Institute of New Jersey
    Principal Investigator: Dr. Deborah Toppmeyer
    Contact: Sherri Damaré, RN at: 732-235-9692 or 732-235-7408

New York

  • New York City
    Beth Israel Medical Center
    Principal Investigator: Dr. Stephen Malamud
    Contact Name: Sherly Jacob-Perez
    Contact Number: 646-601-5899

North Carolina

  • Durham
    Duke University Medical Center
    Principal Investigator: Dr. Paul Marcom
    Contact: Nyssa Schwager, RN: 919-660-1278


  • Hershey
    Penn State Hershey Medical Center
    Principal Investigator: Dr. Allan Lipton
    Contact Name: Cynthia Campbell Baird
    Contact Number: 717-312-3401
  • Philadelphia
    University of Pennsylvania, Basser Research Center for BRCA
    Principal Investigator: Susan Domchek, MD
    Contact Name: Rebecca Cimildoro, RN
    Contact Phone: 215-662-7383
  • Pittsburgh
    UPMC Cancer Center
    Magee Women's Hospital
    Principal Investigator: Shannon Puhalla, MD
    Contact Name: Shannon Puhalla, MD at: puhallasl@upmc.edu
    Study Coordinator: Brenda Lee Steele
    Contact Phone: 412-641-2261

South Carolina

  • Charleston
    MUSC Hollings Cancer Center
    Principal Investigator: Dr. Rita Kramer
    Contact: Marietta Gustilo: 843-792-4271


  • Memphis
    The West Clinic
    Principal Investigator: Lee Schwartzberg, MD
    Contact: Tracy Stewart at: 901-683-0055 x 1236


  • Dallas
    Principal Investigator: Dr. Barbara Haley
    Contact Name: Todd Morgan
    Contact Number: 469-250-8369
  • Houston
    The Methodist Hospital
    Principal Investigator: Dr. Jenny Chang
    Contact Name: Maria Nina Salazar
    Contact Number : 713-441-0629


International sites



Czech Republic



Szolnok - Recruiting
Terri L Leahy, BA (847) 935-3179 terri.leahy@abbvie.com
Nancy Falotico (847) 937-0370 nancy.falotico@abbvie.com
Refer to site reference ID/Investigator#63928




Russian Federation



Page updated 01/30/13

Disclaimer: Health links are made available for educational purposes only. This information should not be interpreted as medical advice. All health information should be discussed with your health care provider. Please read our full disclaimer for more information.

Privacy Policy | Sitemap | Contact Us


This site has been made possible by a generous grant from Morphotek.

Web design by Rareheron Web Design

copyright © FORCE: Facing Our Risk of Cancer Empowered, Inc.  •  info@facingourrisk.org