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Olaparib in Combination With Carboplatin for Refractory or Recurrent Women's Cancers

Study identifier: NCT01237067
Full study details on clinicaltrials.gov

Name of PARP Inhibitor used in study:

Olaparib (AstraZeneca)


  • Patients must have confirmed at the NCI, histologically or cytologically recurrent/refractory epithelial ovarian, fallopian, primary peritoneal, uterine papillary serous cancer, or malignant mixed mullerian tumor.
  • All patients must have measurable and/or evaluable disease; biomarker-only disease is not considered measurable or evaluable.
  • Ovarian or endometrial cancer patients with deleterious mutation in DNA repair enzymes may be treated in first recurrence independent of platinum-sensitivity history.
  • Patients must be at least 6 months from their last platinum exposure and platinum-resistant patients may participate.

Type of study:

Phase I study


Patients who enroll will receive olaparib plus carboplatin.

Study site:


National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
Contact: Laura D.Otten, R.N., B.S.N., O.C.N.
Medical Oncology Referral Coordinator 301-451-1228
1-866-611-6310 (Toll Free) ottenl@mail.nih.gov


Page updated 03/26/11

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