Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors
Full study details on clinicaltrials.gov
Name of PARP Inhibitor used in study:
Patients with a BRCA-related malignancy and/or:
- Patients without a known BRCA mutation must have a probability of harboring a BRCA gene mutation as assessed by BRCAPRO computer program
- Patients with a probability of having genetic mutation ≥ 20% or a BRCA mutation based on a non-Myriad test, must have a formal BRCA testing by Myriad Genetic Laboratories
- Patients with known deleterious BRCA 1 or 2 mutation or a mutation of uncertain significance
Patients who refuse BRCA testing not allowed unless they have another acceptable histology
- First- or second-line metastatic colorectal cancer
- Any-line metastatic mucinous ovarian cancer
- Any line of other metastatic gastrointestinal malignancies in which oxaliplatin has shown some activity (i.e., gastric or pancreatic adenocarcinoma)
May have brain metastases that have been treated and stable for 2 months
Type of study:
Patients receive oral veliparib twice daily and oral capecitabine twice daily on 1-7 and 15-21, and oxaliplatin IV over 2 hours on days 1 and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
University of Wisconsin Hospital and Clinics
Contact: George Wilding 608-263-3961 firstname.lastname@example.org
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