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Carboplatin, Paclitaxel, Bevacizumab, and ABT-888 in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Study identifier: NCT00989651
Full study details on clinicaltrials.gov

Name of PARP Inhibitor used in study:

Veliparib (Abbott)


  • Histologically confirmed newly diagnosed ovarian epithelial, fallopian tube, or primary peritoneal carcinoma, including one of the following histologic cell types:
  • Stage II-IV disease defined surgically with either optimal (≤ 1 cm) or suboptimal residual disease
  • Has undergone initial surgery for diagnosis, staging, and cytoreduction within the past 1-12 weeks
  • No current diagnosis of borderline ovarian epithelial tumor (formerly "tumors of low malignant potential") or recurrent invasive ovarian epithelial, primary peritoneal, or fallopian tube cancer treated with surgery only (e.g., stage IA or IB low-grade ovarian epithelial or fallopian tube cancers)
  • More than 5 years since prior chemotherapy for any abdominal or pelvic tumor
  • Prior adjuvant chemotherapy for localized breast cancer is allowed provided it was completed > 3 years ago AND the patient remains free of recurrent or metastatic disease
  • No prior radiotherapy to any portion of the abdominal cavity or pelvis

Type of study:

Phase I


  • Patients receive one of two regimens of bevacizumab, carboplatin, paclitaxel, and veliparib

Study site:


Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
Saint Louis, Missouri, 63110
Contact: David G. Mutch, MD 314-362-3181  

New York
Memorial Sloan-Kettering Cancer Center
New York, New York, 10065
Contact: Katherine M. Bell-McGuinn 212-639-8895

Case Comprehensive Cancer Center
Cleveland, Ohio, 44106-5065
Contact: Clinical Trials Office - Case Comprehensive Cancer Center 800-641-2422

Oklahoma University Cancer Institute
Oklahoma City, Oklahoma, 73104
Contact: Robert S. Mannel, MD 405-271-8787

Rhode Island
Women and Infants Hospital of Rhode Island
Providence, Rhode Island, 02905
Contact: Clinical Trials Office - Women and Infants Hospital of Rhode I 401-274-1122

University of Virginia Cancer Center
Charlottesville, Virginia, 22908
Contact: Linda R. Duska, MD 434-924-5100

University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Madison, Wisconsin, 53792-6164
Contact: Clinical Trials Office - University of Wisconsin Paul P. Carbo 608-262-5223


Page updated 08/31/11

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