Get Updates


FORCE advocates for families facing hereditary breast and ovarian cancer in areas such as access to care, research funding, insurance, and privacy.

Advocacy > Current Actions > FDA Review of Olaparib

| More


Deadline for ACA marketplace enrollment is January 31!

FDA launches Oncology Center of Excellence as part of the National Cancer Moonshot initiative. 

The FDA approved AeroForm, a new tissue expander for women undergoing breast reconstruction. Learn more...

FDA grants accelerated approval to Rubraca for BRCA-related ovarian cancer. Read more...

FORCE attended the CDC's Advisory Committee on Breast Cancer in Young Women meeting

FDA Review of Olaparib

Unfortunately, ODAC voted against approval of olaparib at the conclusion of the June 25, 2014 hearing. While olaparib showed improvement in progression-free survival, it did not show an improvement in overall survival for the women who took it in the clinical trials. Because there are no approved maintenance drugs currently on the market for ovarian cancer, the trials compared the side effects of olaparib to a placebo (i.e. no treatment at all). Olaparib had more side effects and adverse events than the placebo, so the advisory committee decided the benefits didn't outweigh the risks.

The panel did not take into account the fact that taking olaparib delays a woman's need to go back on chemotherapy; a treatment shown to be more toxic than olaparib. While this vote is not the final decision, the FDA will likely follow ODAC's recommendation and the therapy will be reconsidered after the conclusion of additional research. See our blog about this decision and learn more about PARP inhibitors.

Page updated 7/28/14

FORCE:Facing Our Risk of Cancer Empowered