Advocacy

FORCE advocates for families facing hereditary breast and ovarian cancer in areas such as access to care, research funding, insurance, and privacy.

Advocacy > Issues > FDA Approval of Lynparza: A Win for the HBOC Community

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Newsflash

2/7/2018
FORCE staff and advocates joined stakeholders for a "BRCA Community Perspectives on Data Sharing" workshop in Santa Cruz, CA.

2/6/2018
We joined nearly 40 patient and health care professional organizations in expressing opposition to proposed national right-to-try legislation. Read the letter...

1/17/2018
FORCE submitted comments on a draft CMS Policy on NGS for Medicare Beneficiaries with Advanced Cancer.

1/3/2018
PALS Act moratorium extended to January 2019, preserving insurance coverage of mammograms for women ages 40-49. Read more...

12/20/2018
Court vacates EEOC wellness program rules effective January 1, 2019 signaling end to coercive practices.

FDA Approval of Lynparza: A Win for the HBOC Community

Treatments & Therapies

Overview

FORCE was one of a handful of advocacy organizations to testify in favor of accelerated approval of olaparib at the FDA hearing of the Oncology Drug Advisory Committee (ODAC) in June 2014. ODAC voted against approval at the conclusion of that meeting and early word from the FDA was that more research was needed before it would approve this therapy. The BRCA cancer community is grateful that the FDA reconsidered and approved this treatment.

PARP inhibitors are “targeted therapy” drugs that target tumors based on their unique biology. Developing these “smart” drugs requires a greater understanding of how cancer cells differ from other cells, and identifying cellular vulnerabilities. Targeted therapy uses specific treatments to attack the weaknesses of certain cancers based on their cellular genetic traits. PARP inhibitors block an enzyme used by cells to repair damage to their DNA. In people with BRCA mutations, PARP inhibitors may work by keeping cancer cells from repairing themselves once they’ve been damaged by chemotherapy, while sparing healthy cells.

Despite early positive findings, PARP inhibitor research almost came to a halt several years ago due in part to the challenge of studying drugs that may only benefit small subsets of a larger cancer patient population. Fortunately, thanks to champions within the scientific, advocacy and biotech communities, this important research continued. FDA approval of Lynparza is the culmination of these ongoing efforts, and hopefully only the beginning for this promising class of drugs. See our blog about this decision and read our article on this milestone.

PARP inhibitors are being studied as treatment for a variety of BRCA and BRCA-like cancers. FORCE continues for support these efforts via encouraging genetic testing of those diagnosed with cancer and supporting clinical trial enrollment.  

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