FORCE’s eXamining the Relevance of Articles for Young Survivors (XRAYS) program is a reliable resource for breast cancer research-related news and information. XRAYS reviews new breast cancer research, provides plain-language summaries, and rates how the media covered the topic. XRAYS is funded by the CDC.
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Special populations: People with a family history of male breast cancer
Recent headlines describe the rise in prophylactic double mastectomy for men with breast cancer. This week, we look at the research to see how many men are choosing this option and what it means for men with breast cancer.
Trends and factors associated with the decision to undergo prophylactic double mastectomy among men with cancer in one breast.
Researchers have seen the rates of double mastectomy increase in women with breast cancer but they do not know if this increase is also true for men.
This study indicates an increase in the rate of men choosing double mastectomy between 2004-2005 and 2010-2011. However, it is important to note that most men with breast cancer have a unilateral mastectomy (approximately 75% of men in 2004-2005 and 2010-2011 chose this option). The decision to undergo a single or double mastectomy should be a personal, individual one, made in consultation with your healthcare provider.
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Researchers have noted increased rates of double mastectomy in women diagnosed with invasive cancer in one breast. This trend is especially true for younger women. Factors that researchers believe contribute to the increased rates of double mastectomy include:
Although more women are opting to undergo double mastectomy – which comes with a risk of complications and costs – studies have not shown a survival benefit from the surgery. Unlike women, the double mastectomy rates among men with cancer in one breast and the various factors that contribute to their decisions are unknown.
Whether the double mastectomy rate in men has increased.
6332 men who:
The researchers note that studies have found that increased BRCA testing has increased prophylactic mastectomy rates in women with breast cancer. This research was not able to look at the BRCA status of those in the study population. However, because 40% of male breast cancer is linked to BRCA2 mutations, it is possible that a sizable number of study participants may have been found to be BRCA carriers.
According to study author Dr. Ahmedin Jemal, quoted in a Newsweek, article, “it’s important for male patients to ask a physician about their individual risk for contralateral breast cancer before making any decisions about the surgery…It’s only the patients at high risk who are likely to benefit from the procedure.”
Although not as much research has been done on men with breast cancer, we do know that those with a BRCA2 mutation have a 7% risk of developing breast cancer by age 70. No studies, however, look at the risk of a second breast cancer diagnosis in men with BRCA2 mutations. By looking only at male survival rates and failing to also look at recurrence rates, researchers are unable to consider the possibility that double mastectomy may be decreasing the occurrence of a second cancer, helping these patients avoid further treatment.
In women without a BRCA mutation, the chance of a second breast cancer diagnosis 10 years after the initial diagnosis is approximately 10%. The risk is 10%-30% for breast cancer survivors with a BRCA mutation.
Additionally, it is important to note that the researchers were able to see a significant difference in the rate of double mastectomy only between the years 2004-2005 and 2010-2011. They were unable to see any significant differences when comparing rates in 2004-2005 to those in 2006-2007 or in 2008-2009. Although the lack of a rate increase between 2006 and 2009 may strengthen the researchers’ argument that the increased rate of double mastectomy is, in fact, new, more data needs to be collected to ensure the trend is stable rather than something unique to 2010 and 2011.
For both men and women, the decision to undergo a prophylactic mastectomy should be an individual, personal one, made by patients in consultation with their healthcare providers. Although the data from this study indicate the rates of this surgery in men with breast cancer have increased, more research is needed, both to understand why the rates have increased and to determine if there is a subset of men who will benefit from the procedure.
Firger, J. “Rise Seen in Preventative Mastectomy for Male Breast Cancer Patients.” Newsweek. Published September 2, 2015.
Jemal A, Lin C, DeSantis C et al. “Temporal Trends in and Factors Associated with Contralateral Prophylatic Mastectomy Among US Men With Breast Cancer.” JAMA Surgery, Initially published online September 2, 2015.
Komen. “Inherited Gene Mutations,” updated 1/22/15
Schrag D, Kuntz KM, Garber JE, et al. “Life expectancy gains from cancer prevention strategies for women with breast cancer and BRCA1 or BRCA2 mutations.” JAMA. 283 (5): 617-24, February 2, 2000.
Tai YC, Domchek S, Parmigiani G, et al. “Breast cancer risk among male BRCA1 and BRCA2 mutation carriers.” J Natl Cancer Inst. 99(23): 1811-4, December 5, 2007.
FORCE page: Male breast cancer