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New research suggests exercise is safe for breast cancer patients at risk for lymphedema


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Checked Special populations: Women at risk for lymphedema after lymph node biopsy or radiation

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Patients and health care providers are often concerned about how exercise affects lymphedema (swelling in the arm or hand) in breast cancer survivors or other women who have had lymph node biopsy at the time of mastectomy. Research on this topic has been mixed. A new study suggests that exercise after breast cancer treatment does not lead to lymphedema or worsen existing lymphedema. However, because this study was small, more work needs to be done to understand the relationship between exercise and lymphedema in cancer survivors. (2/22/17)


STUDY AT A GLANCE

This study is about:

How exercise affects lymphedema (swelling in the arm or hand) that can occur after breast cancer treatment.

Why is this study important?

Over the years, research on the relationship of exercise to lymphedema has had mixed results; some studies suggested that exercise could cause cancer patients to develop lymphedema or make their current lymphedema worse, while other studies found that a gradual exercise program helps patients with lymphedema.

Study findings: 

After 6 months of resistance exercise training, the extent of lymphedema did not change significantly.

What does this mean for me?

This study suggests that women who have been treated for breast cancer can perform moderate-intensity exercise (including aerobic and strength exercises) without developing lymphedema or making their existing lymphedema worse. However, as other research studies in the literature contradict these findings, more work is needed to fully understand the relationship between exercise and lymphedema development. Breast cancer survivors and women who have had mastectomy should report any symptoms of lymphedema to their health care providers, and consult with them before beginning any type of exercise program.

Questions to ask your health care provider:

  • I recently completed breast cancer treatment; am I ready for an exercise program?
  • I had breast surgery to treat breast cancer; what types of exercises are right for me?
  • Am I at risk for lymphedema after breast surgery or radiation?
  • What are the symptoms of lymphedema?
  • What should I do if I notice swelling in my arm or hand?
  • How can exercise affect lymphedema?
  • Are there ways to reduce the adverse symptoms of lymphedema
  • Besides lymphedema, what other side effects of breast cancer treatment should I know about?

IN DEPTH REVIEW OF RESEARCH

Study background:

Lymphedema, a swelling of the arm or hand due to lymph node damage, is an adverse side effect that often occurs after breast cancer treatment. Currently there is no cure for lymphedema. Patients who develop this condition can ultimately experience symptoms such as changes in sensation in the arms, a greater feeling of fatigue, and decreased quality of life. Other side effects of breast cancer treatment include decreased bone health and increased fat mass. Strength or resistance exercises can help patients to improve their bone health and weight gain that may occur.  However, some research suggests that resistance exercise may cause patients to develop lymphedema or make it worse.

Emily Simonavice and colleagues from the School of Health and Human Performance in George College and State University and other institutions studied the effect of resistance exercise in women who were treated for breast cancer; their results were published in the journal Supportive Cancer Care. This is one of several recent studies that suggests that strength exercise is safe for breast cancer survivors and does not cause lymphedema or make existing lymphedema worse.

Researchers of this study wanted to know:

How does exercise affect lymphedema in women who have been treated for breast cancer?

Population(s) looked at in the study:

  • Study participants included 25 women who:
    • had breast cancer between stages 0-III
    • completed all primary treatments (surgery, radiation, and/or chemotherapy) at least 6 months before the study started
  • Initially, 27 women began the study, but two dropped out due to clinical complications unrelated to lymphedema. However, data from these women while they were in the study were collected and included in the results.
  • Three of the women already had lymphedema when the study began.
  • Each woman had 2-hour, moderate resistance exercise training sessions per week, which included an aerobic warm-up and exercises targeting all major muscle groups (such as chest presses, leg presses, biceps curls).
  • The presence and/or extent of lymphedema was determined by measuring each woman’s arm circumference every two weeks.

Study findings: 

  1. After 6 months of resistance exercise training the extent of lymphedema did not change significantly.

Limitations:

These findings are preliminary because this study did not include a control group. Although all of the women included in the study performed the moderate resistance training, the researchers could not compare lymphedema between women who did and did not exercise (no information was available regarding the arm circumference changes of breast cancer survivors who did not exercise over the same period). It was also a relatively small study: just 27 women. Additionally, the study included only 3 women who already had lymphedema; too small to generalize the findings to all women with lymphedema. Another reason that this study cannot be generalized is because participants had different combinations of surgery, radiation, chemotherapy, and lymph node dissection (not all women had all four treatments). Finally, the study also looked only at breast cancer survivors. The effects of exercise on previvors after risk-reducing mastectomy due to a mutation in BRCA or other gene that affects cancer risk is not addressed by this study.

Conclusions:

This study suggests that women who have been treated for breast cancer can exercise without developing lymphedema or making their lymphedema worse. Because of the study’s limitations, however, more work needs to be done to fully understand the relationship between exercise and lymphedema. Other researchers have explored this area—a 2009 paper in the New England Journal of Medicine by Dr. Kathryn Schmitz from the University of Pennsylvania School of Medicine showed that breast cancer patients with existing lymphedema who did resistance exercise had greater improvements in the severity of their self-reported lymphedema symptoms compared to patients who did not exercise. Another recent report of preliminary findings presented at the Cancer Survivorship Symposium Advancing Care and Research in 2017 found no difference in the rates of lymphedema between breast cancer patients who exercised and those who did not.

All women who undergo breast surgery and/or radiation to treat breast cancer or reduce the risk of breast cancer are at risk for lymphedema; having axillary lymph node dissection increases that risk.

Current breast cancer survivorship care guidelines from the American Cancer Society and the American Society of Clinical Oncology recommend that health care providers refer patients with arm swelling or other symptoms of lymphedema to a lymphedema specialist who can recommend appropriate treatment. These guidelines also note that more research is required to develop clear evidence-based recommendations to prevent lymphedema after breast surgery and/or radiation.   Patients concerned about lymphedema should discuss symptoms with their health care providers to determine what treatment or prevention measures are best for them.

Posted 2/22/17

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References

Paskett, ED, Le-Rademacher, J, Oliveri, J, et al. “Prevention of lymphedema in women with breast cancer (BC); Results of CALGB (Alliance) 70305." Abstract 104 from Cancer Survivorship Symposium Advancing Care and Research, presented January 27, 2017.  

Runowicz CD, Leach CR, Henry NL, et al. “American Cancer Society/America Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.” Journal of Clinical Oncology 2016; 34(6): 611-635, February 2016. “Weight lifting in women with breast-cancer-related lymphedema.” 

Schmitz K, Ahmed R, Troxel A, et al. “Weight lifting in women with breast-cancer-related lymphedema.” New England Journal of Medicine 2009; 361(7): 664–673.  

Simonavice E, Kim JS, and Panton L. “Effects of resistance exercise in women with or at risk for breast cancer-related lymphedema.” Supportive Care Cancer. Published online first on Aug. 11, 2016. 

 

Related Information and Resources

Be Empowered Webinar: Exercise and Fitness for Survivors and Previvors

Be Empowered Webinar: How Do I Get Motivated? Changing your lifestyle and diet

FORCE Information: Exercise and Lymphedema

FORCE Information: Sentinel Node Mapping and Axillary Dissection

Joining FORCEs Against Hereditary Cancer Newsletter: Strength Training After Breast Surgery

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